Hitman Chev Chelios is kidnapped by a mysterious Chinese mobster. Three months later, he wakes up to discover his nearly indestructible heart has been surgically removed and replaced with a battery-operated ticker that requires regular jolts of electricity in order to work. After a dangerous escape from his captors, Chev is on the run again, this time from the charismatic Mexican gang boss El Huron and the Chinese Triads, headed by the dangerous 100 year-old elder Poon Dong. Once again turning to Doc Miles for medical advice, receiving help from his friend Kaylo¡'s twin brother Venus, and re-connecting with his girlfriend Eve, who is no longer in the dark about what he does for a living, Chev is determined to get his real heart back and wreak vengeance on whoever stole it, embarking on an electrifying chase through Los Angeles where anything goes to stay alive.